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Saul H Rosenberg Selected Research

navitoclax

3/2015Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
2/2013ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
12/2011The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo.
12/2010Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.
11/2010Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
10/2010The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo.
3/2010Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines.
10/2008ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo.
6/2008Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models.
5/2008ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.

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Saul H Rosenberg Research Topics

Disease

50Neoplasms (Cancer)
01/2021 - 08/2002
7Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2014 - 06/2005
7Lymphoma (Lymphomas)
02/2013 - 06/2005
4B-Cell Lymphoma (Lymphoma, B Cell)
10/2010 - 02/2006
3B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2021 - 02/2013
3Multiple Myeloma
01/2017 - 05/2008
3Thrombocytopenia (Thrombopenia)
10/2014 - 11/2010
3Melanoma (Melanoma, Malignant)
09/2008 - 07/2008
2Prostatic Neoplasms (Prostate Cancer)
01/2020 - 10/2017
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2017 - 10/2010
2Hematologic Neoplasms (Hematological Malignancy)
01/2017 - 11/2009
2Leukemia
03/2015 - 03/2010
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
10/2008 - 02/2007
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2017
1Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2017
1Neutropenia
03/2015
1Cardiac Arrhythmias (Arrythmia)
12/2010
1Hemorrhage
12/2010
1Bronchitis
12/2010
1Pleural Effusion (Pleural Effusions)
12/2010
1Lymphopenia (Lymphocytopenia)
12/2010
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
10/2010
1Arthritis (Polyarthritis)
06/2009
1Carcinogenesis
11/2008
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2008
1Hypotension (Low Blood Pressure)
06/2007
1Glioma (Gliomas)
05/2007
1Carcinoma (Carcinomatosis)
05/2007
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2006
1Weight Loss (Weight Reduction)
06/2005

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
01/2020 - 08/2002
10navitoclaxIBA
03/2015 - 05/2008
5venetoclaxIBA
01/2021 - 02/2013
5Temozolomide (Temodar)FDA LinkGeneric
12/2009 - 05/2007
4Pharmaceutical PreparationsIBA
10/2017 - 03/2003
4Cytotoxins (Cytolysins)IBA
10/2010 - 09/2006
4veliparibIBA
12/2009 - 05/2007
4ABT-737IBA
06/2009 - 06/2005
4Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
06/2007 - 03/2006
4Paclitaxel (Taxol)FDA LinkGeneric
09/2006 - 06/2005
4Farnesyltranstransferase (Farnesyltransferase)IBA
11/2005 - 04/2003
3DNA (Deoxyribonucleic Acid)IBA
05/2007 - 02/2005
2AndrogensIBA
01/2020 - 10/2017
2Glucose (Dextrose)FDA LinkGeneric
01/2017 - 06/2005
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2010 - 05/2007
2Etoposide (VP 16)FDA LinkGeneric
10/2010 - 02/2007
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2009 - 07/2008
2Poly Adenosine Diphosphate RiboseIBA
12/2009 - 10/2008
2PolymersIBA
12/2009 - 09/2008
2TubulinIBA
07/2009 - 09/2004
2ABT751IBA
07/2009 - 09/2004
2Sirolimus (Rapamycin)FDA Link
10/2008 - 06/2005
2Poly(ADP-ribose) Polymerase InhibitorsIBA
07/2008 - 05/2007
2Cisplatin (Platino)FDA LinkGeneric
07/2008 - 05/2007
2pyridineIBA
06/2007 - 07/2006
2SurvivinIBA
06/2007 - 01/2003
2Antimitotic AgentsIBA
07/2005 - 09/2004
1ABBV-744IBA
01/2020
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
10/2017
1Androgen Receptors (Androgen Receptor)IBA
10/2017
1CREB-Binding ProteinIBA
10/2017
1Histones (Histone)IBA
10/2017
1Histone Deacetylase InhibitorsIBA
10/2017
1mivebresibIBA
01/2017
1NAD (NADH)IBA
01/2017
1Docetaxel (Taxotere)FDA Link
03/2015
1A-1155463IBA
10/2014
1Transaminases (Aminotransferases)IBA
12/2010
1Vincristine (Oncovin)FDA LinkGeneric
10/2010
1Rituximab (Mabthera)FDA Link
10/2010
1Bortezomib (Velcade)FDA Link
10/2010
1O(6)-Methylguanine-DNA MethyltransferaseIBA
12/2009
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2009
1Caspase 3 (Caspase-3)IBA
10/2008
1Cytostatic AgentsIBA
10/2008
1Adenosine Diphosphate Ribose (ADP-Ribose)IBA
09/2008
1Aurora Kinase AIBA
08/2008
1benzimidazoleIBA
07/2008
1Cytochromes c (Cytochrome c)IBA
05/2008
1IndazolesIBA
06/2007
1Carboplatin (JM8)FDA LinkGeneric
05/2007
1Checkpoint Kinase 1IBA
12/2006
14- (3- dimethylamino- 1- phenylsulfanylmethylpropylamino)- N- (4- (4,4- dimethylpiperidin- 1- yl)benzoyl)- 3- nitrobenzenesulfonamideIBA
09/2006
12-oxindole (oxindole)IBA
07/2006
1Biological ProductsIBA
03/2006
1ABT-100IBA
11/2005
1Phosphotransferases (Kinase)IBA
06/2005
1CamptothecinIBA
02/2005
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2005
1Fluorouracil (Carac)FDA LinkGeneric
02/2005
1AntimetabolitesIBA
02/2005
1Topoisomerase InhibitorsIBA
02/2005
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
09/2004

Therapy/Procedure

19Therapeutics
01/2020 - 08/2004
4Drug Therapy (Chemotherapy)
07/2009 - 02/2006
1Castration
10/2017
1Withholding Treatment
06/2008
1Oral Administration
05/2008
1Anesthesia
09/2004
1Radiotherapy
08/2004